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Antinuclear Antibody Definition

From Jeri Jewett-Tennant, MPH, for About.com

Updated: August 11, 2008

About.com Health's Disease and Condition content is reviewed by our Medical Review Board

Definition: Anitbodies or substances produced by the immune system that attack the body's own tissues.

The antinuclear antibody test (ANA test) is used to screen for these antibodies, which are a marker of autoimmune diseases such as systemic lupus erythematosus). It is not used to diagnose it, however.

The normal titer -- a metric used to measure the presence and amount of antibodies in blood -- of ANA is 1:40. Higher titers in the presence of symptoms are more indicative of an autoimmune disease.

Also Known As: ANA
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