What is Trexall?:
Trexall (methotrexate) is an antimetabolite and antifolate drug used in both the treatment of cancer and certain autoimmune diseases. Its use in lupus has not been thoroughly tested, but it has been shown to improve joint pain and stiffness in lupus patients who have arthritis. It is only modestly effective for organ-threatening lupus.
How Does Trexall Work?:
Trexall works by slowing the growth rate of certain cells.
Who Shouldn't Take Trexall?:
- Pregnant women
- Breastfeeding women
- Those allergic to the drug
- Those with bone marrow disease, liver disease, low blood counts, or poor kidney function
Things to Tell Your Doctor if You're Taking Trexall:
Tell your doctor if you are taking any of the following drugs or supplements:
- antibiotics, such as chloramphenicol, penicillins, and tetracycyline
- folic acid
- aspirin or other nonsteroidal anti-inflammatory medications, such as ibuprofen or naproxen
- other rheumatoid arthritis drugs, such as phenytoin, probenecid, or sulfonamides
Also tell your doctor:
- if you're taking Trexall before any surgery, including dental surgery
- if you have/have had excess fluid in your stomach area or in the space around your lungs
- if you have/have had kidney disease or liver disease, including hepatitis
- if you're receiving radiation therapy
When Should You Take Trexall?:
Well tolerated by most patients, it is usually taken orally on a weekly basis. It can also be delivered by injection. Your doctor will determine your treatment regimen.
Side Effects of Trexall:
- Swollen, tender gums
- Headache
- Hair loss
- Acne
- Changes in skin color
- Irregular menstrual periods
Serious Side Effects:
Tell you doctor immediately if you suffer any of these more serious side effects:
- Chest pain
- Fainting
- Blurred vision
- Sudden loss of vision
- Slurred speech or difficulty speaking
- Difficulty moving one or both sides of the body
- Seizures
- Pain or redness of one leg only
- Rashes, blisters
- Fever
- Urgent/frequent need to urinate
- Blood in urine
Important Warnings:
Trexall may cause:
- Liver damage
- Lung damage
- Kidney damage
- Decrease in the number of blood cells created by your body
- An increased risk of lymphoma (cancer that starts in the immune system’s cells)
- Miscarriage/termination of pregnancy
Is There a Generic Version of Trexall?:
Methotrexate is the generic name for Trexall.
Are There Any Other Brands of Methotrexate?:
Rheumatrex
Sources: Immunosuppresent Drugs. Lupus Foundation of America.
Methotrexate. Medline Plus. October 1, 2006.
